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Bad/Extensive Metabolizers, CYP2D6 The development with the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Approximately seven% from the population has lessened activity of your CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme program. These folks are “inadequate metabolizers” of debrisoquine, dextromethorphan and tr